TAK-653 (Osavampator)

TAK-653 (Osavampator)

TAK-653 (osavampator, NBI-1065845): selective AMPA receptor positive allosteric modulator reference compound for in-vitro and non-clinical research.

Description

Overview

TAK-653 (osavampator; also designated NBI-1065845) is a small-molecule, brain-penetrant positive allosteric modulator (PAM) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. As a PAM, TAK-653 has been investigated for its capacity to potentiate AMPA receptor responses to endogenous glutamate while exhibiting minimal direct agonist activity in vitro.

Mechanism & Scientific Context

TAK-653 has been studied for selective potentiation of glutamatergic neurotransmission through GluA-subunit-containing AMPA receptors. Investigators have reported calcium-influx potentiation in heterologous cell models expressing human GluA1i and have examined its profile in transcranial magnetic stimulation (TMS) and pharmaco-EEG paradigms exploring AMPA-receptor pharmacology in healthy volunteers.

Key Features & Specifications

  • Reference compound for AMPA-receptor PAM research
  • Small-molecule, non-peptidic
  • Characterized in published in-vitro and translational pharmacology studies
  • Third-party COA available upon request

Specifications

Property Value
Synonyms Osavampator; NBI-1065845
CAS Number 1358751-06-0
Molecular Formula C19H23N3O3S
Molecular Weight 373.47 g/mol
Net Content 30 mL solution (per catalog SKU L-021)

Research Applications

TAK-653 appears in the literature alongside research on excitatory neurotransmission, synaptic plasticity, AMPA-receptor pharmacology, and translational biomarker development (TMS-evoked cortical excitability, qEEG). Investigators have explored it in non-clinical models examining glutamate-dependent signaling.

Storage, Handling, Stability

Store sealed at -20 °C protected from light. Allow vial to equilibrate to room temperature before opening to minimize condensation. Reconstituted solutions are generally handled at 2–8 °C for short-term laboratory use; freeze aliquots for longer storage. Avoid repeated freeze-thaw cycles.

Safety & Regulatory Notes

Reference compound for laboratory research, sold strictly for in-vitro and non-clinical research applications by qualified professionals. Not for human or veterinary use. Handle in accordance with general laboratory good practice. No structure-function claims.

Frequently Asked Questions

What is TAK-653?

TAK-653 (osavampator, NBI-1065845) is a small-molecule positive allosteric modulator of AMPA receptors studied in non-clinical glutamatergic-signaling research.

How does TAK-653 differ from an AMPA agonist?

Researchers have reported that TAK-653 potentiates AMPA receptor responses only in the presence of endogenous glutamate and exhibits minimal direct agonist activity in vitro, distinguishing it from full agonists.

What molecular target does TAK-653 act on?

It binds to an allosteric site on AMPA-subtype ionotropic glutamate receptors and potentiates receptor-mediated currents and calcium influx in heterologous expression systems.

What translational biomarkers have been used to characterize TAK-653?

Published work has examined TMS-evoked cortical excitability and pharmaco-EEG endpoints to characterize central AMPA-receptor engagement in healthy-volunteer studies.

How should TAK-653 be stored?

Store sealed at -20 °C protected from light; equilibrate to room temperature before opening; aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

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